Absolutely! If you don’t need the web app and only want to design with the Mac app, you can still get a Mac-only license for $120 yearly.
Keep in mind that you’d need to save all your work locally. You’d also miss out on loads of handy collaborative features that you’d get at the same price of a yearly subscription, such as real-time collaboration in the Mac app, commenting, handoff in the web app, and a shared Workspace to bring all your people and documents together.